Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids.
|
7705931 |
1995 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Hyperalgesia
|
0.320 |
Biomarker
|
phenotype |
BEFREE |
Protein kinase C ε (PKCε) AS-ODN also prevented LDM-induced hyperalgesia and priming, whereas analgesia and priming induced by HDM were unaffected.
|
31209174 |
2019 |
Hyperalgesia
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
While PKCepsilon activation can induce acute hyperalgesia in the IB4(+) population, it fails to induce priming.
|
20457222 |
2010 |
Hyperalgesia
|
0.320 |
Biomarker
|
phenotype |
LHGDN |
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
|
16793902 |
2006 |
Hyperalgesia
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
Injection of 5- and 12-lipoxygenase produced hyperalgesia that was not antagonized by inhibitors of PKA, PKCepsilon or MAPK.These findings suggest that: (1). lipoxygenase products of arachidonic acid function as second messengers in the peripheral hyperalgesia induced by agents that act directly on primary afferent nociceptors (epinephrine and prostaglandin E(2)), (2). products of the 5-lipoxygenase and 12-lipoxygenase pathway are involved in this function, and (3). these lipoxygenase products contribute to hyperalgesia at or downstream of protein kinase A and PKCepsilon.
|
12582831 |
2003 |
Hyperalgesia
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.
|
11738263 |
2001 |
Hyperalgesia, Thermal
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, linear analysis results showed that the densities of p-PKCε and Bcl-<sub>XL</sub> had a reverse linear relationship with the degrees of thermal hyperalgesia and mechanical allodynia.
|
30679921 |
2019 |
Mechanical Allodynia
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, linear analysis results showed that the densities of p-PKCε and Bcl-<sub>XL</sub> had a reverse linear relationship with the degrees of thermal hyperalgesia and mechanical allodynia.
|
30679921 |
2019 |
Non-alcoholic Fatty Liver Disease
|
0.310 |
Biomarker
|
disease |
CTD_human |
Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis.
|
29341352 |
2018 |
Non-alcoholic Fatty Liver Disease
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
NAFLD-specific expression and methylation differences were seen for nine genes coding for key enzymes in intermediate metabolism (including PC, ACLY, and PLCG1) and insulin/insulin-like signaling (including IGF1, IGFBP2, and PRKCE) and replicated by bisulfite pyrosequening (independent n = 39).
|
23931760 |
2013 |
Myocardial Infarction
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We therefore studied platelet PKCε expression from 24 patients with myocardial infarction, 24 patients with stable coronary artery disease and 24 healthy subjects.
|
23071564 |
2012 |
Hyperalgesia, Thermal
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Hyperalgesic priming is restricted to isolectin B4-positive nociceptors.
|
20457222 |
2010 |
Mechanical Allodynia
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Thus, while PKCepsilon is present in most dorsal root ganglion neurons, where it can contribute to acute mechanical hyperalgesia, priming is restricted to IB4(+)-nociceptors, including those that are TrkA(+).
|
20457222 |
2010 |
Myocardial Infarction
|
0.310 |
Therapeutic
|
disease |
CTD_human |
Attenuated cardioprotection by ischemic preconditioning in coronary stenosed heart and its restoration by carvedilol.
|
16782078 |
2006 |
Hyperalgesia, Thermal
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Contribution of 5- and 12-lipoxygenase products to mechanical hyperalgesia induced by prostaglandin E(2) and epinephrine in the rat.
|
12582831 |
2003 |
Mechanical Allodynia
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
We evaluated the role of lipoxygenase products of arachidonic acid metabolism in mechanical hyperalgesia induced by epinephrine, an agent that directly sensitizes nociceptors to produce mechanical hyperalgesia via three second messenger signaling pathways, protein kinase A (PKA), protein kinase C epsilon (PKCepsilon), and mitogen activated protein kinase (MAPK).
|
12582831 |
2003 |
Hyperalgesia, Thermal
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.
|
11738263 |
2001 |
Mechanical Allodynia
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat.
|
11738263 |
2001 |
Nonalcoholic Steatohepatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis.
|
29341352 |
2018 |
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats.
|
20665664 |
2010 |
Drug abuse
|
0.300 |
Biomarker
|
group |
CTD_human |
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
|
20098672 |
2010 |
Drug habituation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
|
20098672 |
2010 |
Drug Use Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
|
20098672 |
2010 |
Nodular glomerulosclerosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats.
|
20665664 |
2010 |